Sao Paulo is a megacity of more than 20 million people, one of the largest in the world and the economic and cultural engine of Brazil. Known to locals as Sampa, it's a city of wide avenues, bold architecture and endless energy, with world-class museums, nightlife and one of the best food scenes in South America, shaped by large Italian, Japanese and Lebanese communities.

For a panoramic view of the endless skyline, head to the top of the Edificio Italia or the observation deck of Sampa Sky. Then graze through the Mercado Municipal, famous for its giant mortadella sandwiches, and admire the neo-Gothic Se Cathedral and the elegant Theatro Municipal. Stroll Avenida Paulista, lined with shops and the Sao Paulo Museum of Art, whose collection includes works by Van Gogh, Rembrandt and Picasso. Explore the street art of Beco do Batman in Vila Madalena and the Japanese culture of the Liberdade neighborhood. When you need a break from the concrete, relax in Ibirapuera Park.

Nonstop flights connect Sao Paulo with several U.S. cities, and it's a hub for travel throughout Brazil. I'll plan your stay and connect Sao Paulo with Rio, Iguazu Falls or the coast.